In the hair transplantation process, the pre-implantation holding phase of grafts is a critical period during which cellular stress begins. In this pilot molecular study, the early biological response of hair grafts harvested using the FUE method to 30–60 minutes of ex vivo hyperbaric oxygen exposure was investigated. The findings indicate that while a transient increase in BAX levels was observed at the 30-minute mark, BCL-2 expression significantly increased by the 60-minute mark, and the BAX/BCL-2 ratio decreased. This result is interpreted as a preliminary molecular finding suggesting that hyperbaric oxygen may exert a modulatory effect on early apoptotic signals in hair grafts. However, it should be particularly emphasized that this study is of a pilot nature and requires support from larger patient cohorts, protein level validations, and long-term graft survival follow-ups to clarify clinical benefits.
Source: https://www.dovepress.com/article/download/115112
PDF: CCID-604164-hyperbaric-oxygen-exposure-during-the-holding-phase-modulate